The epidermis serves several essential protective roles for its inhabitants, including acting as a barrier, antioxidative defense and antimicrobial protection. These functions are executed through corneocytes and SC intercellular lipids and their tight relationship enables modulation of one function to have ripple effects onto others protective functions.
Hill’s nutritionists have developed clinical nutrition Prescription Diet Derm Defense specifically tailored for use in dogs to manage environmental sensitivities. This kibble helps visibly nourish and condition the skin barrier while simultaneously normalizing immune responses against environmental irritants.
Contents
HistaGuard ComplexTM
Hill’s Prescription Diet Derm Defense contains Histaguard Complex, a blend of bioactive substances and phytonutrients designed to support skin health. This exclusive complex helps reduce signs of environmental allergies by disrupting internal allergy responses, decreasing inflammation and decreasing itching. Plus, this formula contains vitamin A, zinc and essential fatty acids to rejuvenate skin barrier function and strengthen its strength. With its precise ingredients that avoid common allergens and egg as the sole intact animal protein source, this dietary diet for dogs helps minimize immune reactions to external environmental allergens. Furthermore, its nutritional standards promote urinary health by decreasing risk for struvite and calcium oxalate crystal formation*. *
*Source: Veterinary Dermatology Society of the United States (2017) presented by Hill’s Pet Nutrition Inc.
Omega 3 Fatty Acids
Omega-3 fatty acids, commonly referred to as polyunsaturated fatty acids (PUFAs), can be found both in food products and dietary supplements. As part of cell membrane phospholipids, they have numerous effects on cell receptors including inflammation, vasoconstriction and blood clotting. [2] Three main omega-3 fatty acids include alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). [1] [2] [1] [2] [2] [1] [1] [2] [1] [2] [1] [1] [2] [1] [2] [1] [3] [1] [1] [1] [1][1] [2][2] [2][1][1][1][1][2][1] The three main omega-3 fatty acids are alpha-linolenic acid (ALA), eicosapentaenoic acid) docosahexahexahexaenoic acid DHA].[2] The three primary omega-3s include alpha-linolenic acid (ALA), docosahexaenoic Acid].[2] [3][1][1]
These benefits of omega-3s include their potential to decrease chronic inflammation, which has been linked to obesity, cancer, heart disease and other conditions. Furthermore, omega-3s may help improve cognitive function and lower the risk of Alzheimer’s disease while relieving depression and anxiety symptoms. Furthermore, multiple studies show omega-3s’ potential to lower CRP markers such as levels. [2]
Vitamin A
Vitamin A is an essential nutrient essential for cell development and tissue repair, as well as overall skin and coat health.
Hill’s Prescription Diet Derm Defense Environmental Sensitivities dog food helps reduce itchy skin and excessive shedding by supporting your dog’s immune system. Formulated with HistaGuard complex, an exclusive combination of eggs and antioxidants designed to break the cycle of itching and inflammation caused by allergens. Furthermore, this dietetic kibble also contains Omega 3 and 6 fatty acids for added support in strengthening skin barriers.
Brekz offers Hill’s Prescription Diet Derm Defence for Dogs at an attractive price. This food provides a comprehensive and balanced diet for canines that contains cereals, meat and animal by-products (chicken 6%), vegetable protein extracts, oils and fats, eggs and egg derivatives, seeds and by-products from vegetable origin, as well as minerals.
Zinc
Zinc is an essential trace mineral present in every cell in your body and essential for normal development, growth, cell activity, enzyme production and DNA expression (your genes). Zinc deficiency impairs proliferation, differentiation and survival of keratinocytes while decreasing epidermal growth factor expression levels and leading to increased levels of apoptosis [65].
Zinc oxide has long been used in topical applications to protect against sunburn, reflecting and scattering UV rays away from skin to prevent damage and safeguard its wellbeing. Furthermore, zinc oxide can also help treat burns, leg ulcers and diabetic foot ulcers as well as skin injuries or wounds.
LED illuminated zinc silicate nanoparticle-based scaffolds significantly accelerated healing in burn wounds with innervated and vascularized tissue by increasing human umbilical vein endothelial cells’ angiogenic activity, Schwann cells’ neurogenic function, and blood vessel formation in rats [66]. Zinc also promotes angiogenesis, reduces inflammation, prevents infection, and has proven its antimicrobial properties by significantly reducing bacteria such as MRSA and E. coli from biofilm models – evidenced by significantly reducing MRSA and E. coli biofilm models [67].
